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How is trifluorotoluene use?

Trifluorotoluene is an amoebic admixture with the blueprint of C6H5CF3. This achromatic fluorocarbon is acclimated as a specialty bread-and-butter in amoebic amalgam and an average in the assembly of pesticides and pharmaceuticals.

According to Ogawa and Curran, trifluorotoluene is agnate to dichloromethane in accepted acylation, tosylation, and silylation reactions. The dielectric constants for dichloromethane and trifluorotoluene are 9.04 and 9.18, respectively, apocalyptic agnate solvating properties. Dipole moments analyze beneath favorably: 1.89 and 2.86 D for dichloromethane and trifluorotoluene, respectively. Replacing dichloromethane is advantageous if altitude crave college baking solvents back trifluorotoluene boils 62 °C college than dichloromethane (b.p. 40 °C).

As a solvent, trifluorotoluene is advantageous in balmy Lewis-acid catalyzed reactions, such as the Friedel-Crafts preparations. The a lot of accepted catalyst, aluminium trichloride reacts with trifluorotoluene at allowance temperature; however, zinc chloride does not.

A additional and conceivably added admired use of trifluorotoluene is as a constructed intermediate. A acquired of trifluorotoluene, 3-aminobenzotrifluoride, is the forerunner to the herbicide fluometuron. It is actinic via nitration followed by abridgement to meta-H2NC6H4CF3. This aniline is again adapted to the urea.

Flumetramide (6-[4-(trifluoromethyl)phenyl]morpholin-3-one), a ashen beef relaxant, is aswell able from trifluorotoluene.

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