2,3-dinor Thromboxane B2 EIA Kit is rapidly anatomize non-enzymatically to anatomy TXB2. Although it is accepted to appraisal TXA2 levels by barometer TXB2, a lot of of the TXB2 abstinent is due to ex vivo platelet activation or intra-renal production. Altitude errors are circuitous by the actuality that accustomed concentrations of circulating TXB2 are acutely low (1-2 pg/ml), and awful brief (t½ = 5-7 minutes). To avoid this problem, it is all-important to admeasurement a metabolite that cannot be formed by platelets or by the kidney. TXB2 may be metabolized by 11-hydroxy thromboxane dehydrogenase to anatomy 11-dehydro TXB2, or by β-oxidation to anatomy 2,3-dinor TXB2. Infusion studies application TXB2 accept apparent that both metabolites are formed equally, but that the circulating half-life of 2,3-dinor TXB2 is beneath (t½ = 15 minutes). Therefore, altitude of 2,3-dinor TXB2 will accord a added anecdotal adumbration of TXA2 production.
2,3-dinor Thromboxane B2 EIA Kit is a thromboxane. It is produced by activated platelets and has prothrombotic properties: it stimulates activation of new platelets as able-bodied as increases platelet aggregation. This is accomplished by mediating announcement of the glycoprotein circuitous GP IIb/IIIa in the corpuscle film of platelets. Circulating fibrinogen binds these receptors on adjoining platelets, added deepening the clot. Thromboxane A2 is aswell a accepted vasoconstrictor and is abnormally important during tissue abrasion and inflammation. It is aswell admired amenable for Prinzmetal’s angina. Receptors that arbitrate TXA2 accomplishments are thromboxane A2 receptors. The animal TXA2 receptor (TP) is a archetypal G protein-coupled receptor (GPCR) with seven transmembrane segments. In humans, two TP receptor braid variants – TPα and TPβ – accept so far been cloned.