Cisapride works on the acetylcholine absolution and blocks the dopamine receptors, but to a bottom aftereffect than metoclopramide HCl. This will affect mainly the activity of the GI tract. It acts mainly on the lower esophageal sphincter, increases the burden in the lower allotment of the esophagus. It has appropriately an activating aftereffect on the lower esophageal peristasis and accelerates the elimination of the abdomen agreeable into the intestine, but does not affect belly secretion, and enhances peristalsis of the baby civil and colon. Cisapride is acclimated mainly in the analysis of belly disorders and megacolon.
Cisapride acts through the dispatch of the serotonin 5-HT4 receptors which increases acetylcholine absolution in the enteric afraid arrangement (specifically the myenteric plexus). This after-effects in added accent and amplitude of belly (especially antral) contractions, alleviation of the pyloric sphincter and the belly bulb, and added peristalsis of the duodenum and jejunum consistent in accelerated belly elimination and abdominal transit.
Cisapride is rapidly captivated afterwards articulate administration, with an complete bioavailability of 35-40%.