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Effect of Lycopene on Hepatoprotection

Liver accident is associated with cellular necrosis, access in tissue lipid peroxidation, and burning of tissue GSH levels. In addition, serum levels of abounding biochemical markers like serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, triglycerides, cholesterol, bilirubin, and acrid phosphatase are animated if alarmist accident is present. The hepatoprotective aftereffect of lycopene was evaluated adjoin galactosamine/lipopolysaccharide (D-GalN/LPS)-induced hepatitis in rats. Lycopene at a dosage of 10 mg/kg (intraperitoneal) decidedly bargain the levels of cholesterol, triglycerides, and chargeless blubbery acids, followed by a abatement in the levels of phospholipids in the serum and the liver. Another abstraction approved lycopene decidedly adequate antioxidant alarmist enzymes, such as glutathione peroxidase, glutathione-s-transferase, adjoin N-methyl-N′-nitro-N-nitrosoguanidine, and saturated sodium chloride (S-NaCl)-induced belly carcinogenesis.

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