Mesaconic acid is one of several isomeric carboxylic acids acquired from citric acid. It is the trans-isomer of citraconic acid. It is acclimated as a blaze retardant.
Mesaconic acid was advised for the aboriginal time by Dutch chemist Jacobus H. van ‘t Hoff in 1874. Later American biochemist Horace Albert Barker and his aggregation auspiciously abandoned this acerbic from crumbling bacillus Clostridium tetanomorphum in 1950s. Further studies led him to ascertain this amoebic admixture was complex in vitamin B12 coenzymes synthesis.
Recent studies appear this acerbic is a aggressive inhibitor of fumarate reduction.