Diacerein is a diacetyl forerunner of rhein, an anthraquinone begin in plants. Rhein, at 10 µM, inhibits IL-1β signaling, suppressing signaling through NF-κB and AP-1, and reduces the announcement of the cast metalloproteases MMP-1 and MMP-13. Diacerein, apparently afterwards about-face to rhein, down-regulates the announcement of the IL-1β receptor on articular chondrocytes, enhances the announcement of TGF-β, and increases collagen and aggrecan. It does not adapt COX activity. It is agilely able in ameliorating osteoarthritis.