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What is Potassium canrenoate (CAS 2181-04-6)?


Synonym: Canrenoic acid potassium salt; Soldactone; Potassium aldadiene
CAS Number: 2181-04-6
Purity: ≥98%
Molecular Weight: 396.56
Molecular Formula: C22H29O4•K
Solubility: Soluble in water (50 mg/ml), ethanol, and alcohol. Insoluble in chloroform, and ether.
Application: A competitive aldosterone antagonist
Storage: Store at room temperature
Description
Potassium canrenoate is a aggressive aldosterone antagonist. It has been apparent to annul the furnishings of aldosterone-induced claret burden increases in animals with top sodium intake. Potassium canrenoate is clinically acclimated for its anti-fibrotic furnishings and has been apparent to abate cardiovascular fibrosis in beastly models. At college concentrations, however, potassium canrenoate has been begin to aftermath genotoxic furnishings to the alarmist and an access in bump accident studies with rodents.
Potassium canrenoate or canrenoate potassium (USAN) (brand names Venactone, Soldactone), aswell accepted as aldadiene kalium,the potassium alkali of canrenoic acid, is an aldosterone adversary of the spirolactone group.Like spironolactone, it is a prodrug, which is metabolized to canrenone in the body. Potassium canrenoate is not accountant in the UK, but may sometimes be assigned off-licence to amusement oedema. It is accustomed intravenously.

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