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Azithromycin Pharmacology

Mechanism of action:
Azithromycin prevents bacilli from growing by interfering with their protein synthesis. It binds to the 50S subunit of the bacterial ribosome, appropriately inhibiting adaptation of mRNA. Nucleic acid amalgam is not affected.
Azithromycin is an acid-stable antibiotic, so it can be taken orally with no charge of aegis from belly acids. It is readily absorbed, but assimilation is greater on an atapeoned stomach. Time to aiguille absorption (Tmax) in adults is 2.1 to 3.2 hours for articulate dosage forms. Due to its top absorption in phagocytes, azithromycin is actively transported to the website of infection. During alive phagocytosis, ample concentrations are released. The absorption of azithromycin in the tissues can be over 50 times college than in claret due to ion accoutrement and its top lipid solubility.Azithromycin’s half-life allows a ample individual dosage to be administered and yet advance bacteriostatic levels in the adulterated tissue for several days.
Following a individual dosage of 500 mg, the credible terminal abolishment half-life of azithromycin is 68 hours. Biliary abolishment of azithromycin, predominantly unchanged, is a above avenue of elimination. Over the advance of a week, about 6% of the administered dosage appears as banausic biologic in urine.


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