It is prepared by the dehydrogenation of pyridine using Raney nickel:
2C5H5N → (C5H4N)2 + H2
Although uncoordinated bipyridine is generally fatigued with its nitrogen atoms in cis conformation, the everyman activity anatomy both in solid accompaniment and in band-aid is in actuality coplanar, with nitrogen atoms in auto position.Protonated bipyridine adopts a cis conformation. Upon bounden to metal ions the accompanying N,N-heterocyclic ligand phenanthroline does not acquire an enthalpic and entropic penalty, and appropriately its complexes tend to be added stable.
Reflecting the acceptance of this ligand design, abounding commissioned variants of bipy accept been described.