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Cefpodoxime Proxetil – Clinical Pharmacology

Cefpodoxime proxetil is an articulate cephalosporin antibacterial used to amusement bacterial infections of the skin, such as wounds and abscesses as able-bodied as float and respiratory infections in dogs and derma and bendable tissue infections in cats. It does not amusement viral or abject infections.
Cefpodoxime Proxetil is a prodrug that is captivated from the gastrointestinal amplitude and de-esterified to its alive metabolite, cefpodoxime. Following articulate administering of 100 mg of Cefpodoxime Proxetil to abnegation subjects, about 50% of the administered cefpodoxime dosage was captivated systemically. Over the recommended dosing ambit (100 to 400 mg), about 29 to 33% of the administered cefpodoxime dosage was excreted banausic in the urine in 12 hours. There is basal metabolism of cefpodoxime in vivo.


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