Valsartan is an angiotensin-receptor acquaintance (ARB) that may be used to amusement a array of cardiac altitude including hypertension, diabetic nephropathy and affection failure. Valsartan lowers claret burden by antagonizing the renin-angiotensin-aldosterone arrangement (RAAS); it competes with angiotensin II for bounden to the type-1 angiotensin II receptor (AT1) subtype and prevents the claret burden accretion furnishings of angiotensin II. Unlike angiotensin-converting agitator (ACE) inhibitors, ARBs do not accept the adverse aftereffect of dry cough. Valsartan may be used to amusement hypertension, abandoned systolic hypertension, larboard ventricular hypertrophy and diabetic nephropathy. It may aswell be used as an another abettor for the analysis of affection failure, systolic dysfunction, myocardial infarction and coronary avenue disease.
Valsartan is an ARB that selectively inhibits the bounden of angiotensin II to AT1, which is begin in abounding tissues such as vascular bland beef and the adrenal glands. This finer inhibits the AT1-mediated vasoconstrictive and aldosterone-secreting furnishings of angiotensin II and after-effects in a abatement in vascular attrition and claret pressure. Valsartan is careful for AT1 and has around no affection for AT2. Inhibition of aldosterone beard may arrest sodium and baptize reabsorption in the kidneys while abbreviating potassium excretion. The primary metabolite of valsartan, valeryl 4-hydroxy valsartan, has no pharmacological activity.